PHOSPHATIDYL SERINE

Phosphatidyl serine and phosphatidic acid complex (PSPATM)

Complete fractionation of brain cephalin; isolation from it of phosphatidyl serine, phosphatidyl ethanolamine, and diphosphoinositide.

Brain cephalin (1) has been the name given to a fraction of brain phosphatides characterized by its solubility in ether and insolubility in ethyl alcohol. For many years it was assumed to be a single compound with the chemical structure of diacylglycerylphosphoryl ethanolamine. Work from this laboratory has shown brain cephalin to be a mixture (2). From it were separated two pure phosphatides; ...

16. Role of Phosphatidyl Serine in the Opiate Receptor*

The molecular nature and configuration of the opiate receptor is a problem under intensive investigation in a number of laboratories (1,2,3). Our interest in the problem developed as a result of a finding of others (4) that a proteolipid fraction from brain may be responsible for stereospecific opiate binding observed in various preparations of brain tissue. Upon examining various lipids, prote...

P-124: Association between Fertilization Rate and Externilization of Phosphatidyl Serine

Background: Externalization of PS (EPS) is considered as a sign of early apoptosis. In addition, EPS also occurs during capacitation and the acrosome reaction. During this study we aimed to evaluate the relationship between EPS and fertilization, embryo quality and pregnancy outcomes in couples who were candidates for ICSI. Materials and Methods: Semen samples (n = 43) were collected from infer...

Role of phosphatidyl-serine in bone repair and its technological exploitation.

In the 1970s, morphological evidence collected by electron microscopy linked mineral deposition ("calcification" or "mineralization") in newly-forming bone to membrane-encapsulated particles of a diameter of approximately 100 nm (50-200 nm) that were called "matrix vesicles". As the characterisation of these vesicles progressed towards their biochemical composition, the role of lipids in the bi...